Physics of Medical Imaging
KTH Royal Institute of Technology

Photon Counting Spectral CT

Computed Tomography (CT) is one of the most commonly used medical imaging procedures for imaging cancer, stroke, cardiovascular disease and more. Every year hundreds of millions of CT scans are performed worldwide.

In our research we are developing the next generation of x-ray CT technology, which uses photon-counting silicon detectors to produce unprecedented image quality. To further enhance the image quality we combine this with advanced AI-based data processing.

Photonova Spectra CT system presented at RSNA
At RSNA Annual Meeting 2025, GE HealthCare unveiled their next flagship CT scanner, Photonova Spectra, based on Deep Silicon technology developed in our research group.

Spectral photon counting CT makes subtle tissue changes easier to see, and replaces the current gray-scale image values with physical measurement of material concentrations. This technology can also reduce the radiation dose, which is particularly important when imaging children since they are more sensitive for radiation.

This is one of the most important milestones in the development of CT, and our research is at the forefront.

Adapted from Grönberg et al. Eur. Radol. 2020
An excised heart specimen from a deceased person, imaged with a silicon-based photon-counting CT prototype. (a) Synthetic monoenergetic image at 70 keV. (b) Detail of (a) showing a blood vessel with calcification and iodinated contrast agent. (c) Material-decomposed image showing calcium (green) and iodine (red). This demonstrates the capability of photon counting CT to quantify iodine and calcium independently, without assuming a volume-preserving mixture. Adapted from Grönberg et al. Eur. Radol. 2020.